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Annexin V + cells were detected upon 5 h treatment with 2-Deoxy-D-glucose

This regulatory status means long-term human safety data remains limited compared to FDA-approved drugs

Strategies for accelerating glucose depletion in tumor cells mainly include the delivery of glucose oxidase (GOx), co-delivery of GOx and oxygen, co-delivery of GOx and oxygen-generating compounds, and photodynamic/photothermal-driven glucose depletion

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